![]() ![]() PCOS was diagnosed based on the Rotterdam criteria (Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group, 2004), including at least two of the following symptoms: oligo/anovulation, biochemical and/or clinical hyperandrogenism and polycystic ovaries on ultrasound, with other androgen excess disorders excluded. ![]() Women who had previous ovarian surgery were excluded due to a possible effect of the surgical intervention on the total antral follicle count (AFC). Only women who never had any hormone treatment, including oral contraceptives, or other relevant medications before having the test of ovarian reserve were eligible. īetween June and October 2014, 268 infertile women due to PCOS were recruited in our study at the Center for Reproductive Medicine, Shandong University. These findings raised concerns that environmental BPA exposure may adversely affect the oocyte quality and cause the decline of ovarian reserve and fertility in the general population, though the magnitude of actual risk in human remains uncertain. In women undergoing in vitro fertilization (IVF) treatment, an inverse association was found between urinary BPA concentrations and oocytes maturation, number of oocytes retrieved and peak estradiol (E2) levels. Moreover, animal studies indicate that BPA has adverse effects on the maturing oocyte and meiotic cell division machinery. A large number of animal experiments suggest that BPA may act as a reproductive toxicant and affect fertilization rate, number of live newborns per litter, the onset of female puberty and estrous cycle. It has been detected in almost all human body fluids, including follicular fluid, which indicates that oocytes are exposed to BPA during the folliculogenesis process. Our results suggest that in women with PCOS, BPA may affect ovarian follicles and, therefore, reduce ovarian reserve.īPA has estrogenic activity and can bind to α- and β-estrogen receptors (ER) both in vivo and in vitro. No association was observed between BPA and INHB. Likewise, BPA was negatively associated with AMH and day-3 FSH levels, but neither of them reached statistical significance. A unit increase in BPA_Cre was associated with a significant decrease of 0.34 in AFC (β = −0.34, 95% CI = −0.60, −0.08 p = 0.01). ![]() BPA was detected in all women with a median concentration of 2.35 ng/mL (the 25th and 75th percentiles of 1.47 ng/mL and 3.95 ng/mL). To better understand possible effects of bisphenol A (BPA) exposure on ovarian reserve in women with polycystic ovary syndrome (PCOS), we measured creatinine adjusted urinary BPA (BPA_Cre) concentrations and used regression models to evaluate the association between urinary BPA level and antral follicle count (AFC), antimullerian hormone (AMH), day-3 follicle stimulating hormone levels (FSH) and inhibin B (INHB) in 268 infertile women diagnosed with PCOS. ![]()
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